Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

RNA-seq

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases.
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while...

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

Sanger Sequencing

Sanger Sequencing

DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Incidence of delirium in hospitalized heart failure patients: a systematic review and meta-analysis.

Frontiers in cardiovascular medicine·2026

Same author

Kappa opioid receptor availability in borderline personality disorder: An in-vivo investigation with [<sup>11</sup>C]EKAP PET imaging.

Biological psychiatry·2026

Same author

Effects of Different Packaging Methods on the Quality of Fresh Red Apricots During Simulated Transportation and Storage After Transportation.

Foods (Basel, Switzerland)·2026

Same author

Reliability-Aware Microsystem Design; Compensation for an Ultra-Low-Power Current-Reuse LC-VCO.

Micromachines·2026

Same author

Widespread synaptic density loss in schizophrenia follows molecular and network architecture.

Molecular psychiatry·2026

Same author

Lower Muscarinic M1 Receptor Availability in Schizophrenia: In Vivo PET Evidence.

Biological psychiatry·2026

Same journal

A Coumarin-Based Probe for Sequential ON-OFF-ON Detection of Cu<sup>2+</sup> and Biothiols: Naked-Eye Detection, Smartphone RGB Readout and In Vivo Imaging.

Biosensors·2026

Same journal

Electropolymerized Molecularly Imprinted Polymers Supported on Carbon-Based Materials for (Bio)sensing: Direct and Indirect Detection Strategies.

Biosensors·2026

Same journal

Progress in (Photo)electrochemical Biosensors for the Detection of Amyloid-Beta Oligomer.

Biosensors·2026

Same journal

Design and Simulation of Lamotrigine Intermittent Release from a Subcutaneous Implant with an Enzymatic Biosensor Based on Clinical Data.

Biosensors·2026

Same journal

Prediction of Chronic Kidney Disease Based on Simulated Serum Analysis by Vibrational Spectroscopy.

Biosensors·2026

Same journal

AI/ML-Assisted SERS Biosensing for Biomolecular Detection: From Direct Spectral Response to Integrated Diagnostic Systems.

Biosensors·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Nanopore DNA Sequencing for Metagenomic Soil Analysis

Nanopore DNA Sequencing for Metagenomic Soil Analysis

Published on: December 14, 2017

Nanopore-CMOS Interfaces for DNA Sequencing.

Sebastian Magierowski¹, Yiyun Huang², Chengjie Wang³

¹Department of Electrical Engineering and Computer Science, York University, 6400 Keele St, Toronto, ON M3J-1P3, Canada. magiero@eecs.yorku.ca.

|August 11, 2016

Summary

This summary is machine-generated.

Nanopore DNA sequencing offers a breakthrough with simplified chemistry and CMOS integration for faster, smaller, and cheaper genetic analysis. This technology promises to revolutionize DNA sequencing by overcoming limitations of current methods.

Keywords:

CMOS microelectronics nanopore arrays nanopore sensors sequencing transimpedance amplification

More Related Videos

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Related Experiment Videos

Last Updated: Mar 16, 2026

Nanopore DNA Sequencing for Metagenomic Soil Analysis

Nanopore DNA Sequencing for Metagenomic Soil Analysis

Published on: December 14, 2017

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Sequencing of mRNA from Whole Blood using Nanopore Sequencing

Published on: June 3, 2019

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Fine-tuning the Size and Minimizing the Noise of Solid-state Nanopores

Published on: October 31, 2013

Area of Science:

Biotechnology and Biomedical Engineering
Genomics and Molecular Biology

Background:

Current DNA sequencing technologies rely on template-based methods developed over the past forty years.
Nanopore sensors offer a novel approach to DNA sequencing with potential advantages over existing techniques.

Purpose of the Study:

To review and analyze existing and emerging methods for interfacing nanopores with CMOS technology.
To contextualize nanopore sequencing within the landscape of incumbent DNA sequencing techniques.
To explore the potential for massively-arrayed nanopore structures for enhanced sequencing capabilities.

Main Methods:

Review of current and developing nanopore-CMOS interfacing strategies.
Quantification and modeling of nanopore characteristics.
Presentation of CMOS circuit designs for amplifying low-current nanopore signals.

Main Results:

Nanopore technology offers simplified chemistry and CMOS compatibility, enabling potential improvements in sequencing speed, size, and cost.
Analysis of nanopore characteristics and modeling provides insights into their performance.
CMOS circuit methods are presented for effective amplification of weak nanopore signals.

Conclusions:

Nanopore DNA sequencing, particularly with CMOS integration and massively-arrayed structures, represents a significant advancement over traditional methods.
This technology holds promise for more accessible, rapid, and cost-effective DNA sequencing.
Further development in nanopore-CMOS interfacing is crucial for realizing the full potential of this sequencing approach.