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Barriers to HIV Medication Adherence as a Function of Regimen Simplification
Yiyun Chen1, Kun Chen2, Seth C Kalichman3
1Psychological Sciences, University of Connecticut, Storrs, CT, 06268, USA.
Summary
Simplifying HIV medication regimens to single-tablet regimens (STR) improves adherence. Interventions should address regimen-specific barriers for people living with HIV to enhance treatment outcomes.
Area of Science:
- HIV/AIDS Research
- Pharmacology
- Public Health
Background:
- Medication adherence is crucial for managing HIV.
- Dosing schedule complexity can present barriers to adherence.
Purpose of the Study:
- To investigate adherence barriers related to medication regimen complexity and simplification.
- To compare adherence rates across different antiretroviral therapy (ART) dosing schedules.
Main Methods:
- 755 people living with HIV (PLWH) on ART were recruited in Atlanta, Georgia.
- Audio-computer-assisted self-interviews assessed demographics and behaviors.
- Unannounced pill counts monitored adherence over one month.
Main Results:
- Single-tablet regimen (STR) users showed higher adherence than multi-tablet regimen (MTR) users.
- STR users reported fewer scheduling issues and less confusion.
- Lifestyle and logistical barriers were reported equally across regimen types.
Conclusions:
- Adherence interventions should be tailored to specific dosing regimens.
- Simplifying regimens, such as through STRs, may enhance HIV treatment adherence.
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