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NF-κΒ and SOD expression in preeclamptic placentas
Abraham Silva Carmona1, Hugo Mendieta Zerón2
1Hospital General de México, SSA, Mexico City, Mexico.
Background/Aim:
Preeclampsia is a leading cause of maternal death in the developing world. Our aim was to quantify and compare messenger (mRNA) expression of nuclear factor-kappa beta (NF-κΒ) and superoxide dismutase (SOD) in control patients with preeclampsia and without preeclampsia with or without familial hereditary background.
Materials And Methods:
Four groups of patients were formed depending on the presence or absence of preeclampsia and presence or absence of familial history for preeclampsia. NF-κΒ and SOD were measured in human placentas by real-time quantitative polymerase chain reaction. The 2-ΔΔct analysis method was used to measure the difference in the relative expression of the target genes in each group of patients.
Results:
In NF-κΒ expression, there was an increase of 23.35% in the group of women with preeclampsia versus women with preeclampsia without familial history. Regarding SOD, there was a reduction of about 33.33% in the expression in women with preeclampsia with familial history versus women with preeclampsia without familial history.
Conclusion:
Familial presence of preeclampsia could predispose to altered expression in SOD and NF-κΒ.
