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High-throughput Fluorometric Measurement of Potential Soil Extracellular Enzyme Activities
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[Not Available].

María Sese1, Luis A Moreno, Laura Censi

  • 1GENUD Research Group. david.jimenez@uca.es.

Nutricion Hospitalaria
|August 12, 2016
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Summary
This summary is machine-generated.

High body fat is linked to insulin resistance in adolescents. Lean mass appears to play a role, but its association with insulin resistance is influenced by overall body fat levels.

Keywords:
Insulin resistance. Adolescent. Body fat. Obesity.

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Area of Science:

  • Endocrinology
  • Metabolic Health
  • Adolescent Health

Background:

  • Body composition significantly influences metabolic health.
  • Insulin resistance and type 2 diabetes mellitus are growing concerns in adolescents.
  • Understanding the interplay of different body components is crucial for metabolic health research.

Purpose of the Study:

  • To investigate the independent associations of fat mass and fat-free mass with insulin resistance markers.
  • To provide gender-specific insights into these relationships in European adolescents.
  • To clarify the role of body composition in adolescent insulin resistance.

Main Methods:

  • Cross-sectional study of 925 European adolescents (mean age 14.9 years).
  • Measurements included anthropometrics, bioimpedance, and blood parameters.
  • Multiple regression analyses were used, adjusting for confounders and body composition indices.

Main Results:

  • Fat mass indices showed a significant positive association with insulin resistance (HOMA) in both sexes, independent of fat-free mass.
  • Fat-free mass indices were associated with insulin resistance, but this association diminished when fat mass was included in the model.
  • Gender-specific associations were observed, highlighting differential impacts of body composition.

Conclusions:

  • Increased fat mass is a key independent predictor of insulin resistance in adolescents.
  • The association between fat-free mass and insulin resistance is modulated by the amount of fat mass.
  • Future research should consider both fat mass and fat-free mass, along with their interplay, in understanding adolescent metabolic health.