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Updated: Mar 16, 2026

An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP
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An Experimental Paradigm for the Prediction of Post-Operative Pain PPOP

Published on: January 27, 2010

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[PROPHYLAXIS OF POSTOPERATIVE HYPERALGESIA, BASED ON MORPHOLOGICAL SUBSTANTIATION OF THE ANALGESIA METHOD]

D V Dmytriyev, V S Konoplytskyi

    Klinichna Khirurhiia
    |August 13, 2016
    PubMed

    Insights

    High-dose fentanyl infusions in pediatric cancer surgery may cause opiate-induced hyperalgesia and intestinal changes. Transversus abdominis plane blockade and combined spinal epidural analgesia did not show these adverse effects.

    Area of Science:

    • Pediatric surgery
    • Pain management
    • Oncology

    Context:

    • Abdominal oncological diseases in children require effective perioperative pain management.
    • Previous analgesia methods may have unaddressed side effects.
    • Understanding the impact of different anesthesia techniques on pediatric patients is crucial.

    Purpose:

    • To compare the effects of different analgesia methods on perioperative pain and potential complications in children undergoing abdominal cancer surgery.
    • To investigate the occurrence of opiate-induced hyperalgesia and associated morphological changes in the intestinal wall.

    Summary:

    • A study involving 20 children with abdominal oncological diseases (2010-2015) evaluated various analgesia methods.
    • High-dose fentanyl (1-4 MKr/kg/h) infusion perioperatively was associated with opiate-induced hyperalgesia and intestinal wall morphological changes.
    • Transversus abdominis plane blockade and combined spinal epidural analgesia did not result in these observed changes.

    Impact:

    • Identifies potential risks associated with high-dose fentanyl in pediatric cancer patients.
    • Suggests that transversus abdominis plane blockade and combined spinal epidural analgesia may be safer alternatives for pain management in this population.
    • Informs clinical practice regarding the choice of analgesia to minimize adverse effects in pediatric abdominal oncology surgery.

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