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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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[ANTENATAL APPLICATION OF CORTICOSTEROIDS IN LATE PRETERM BIRTHS].

M Mladenova, E Uchikova, E Dimitrakova

    Akusherstvo I Ginekologiia
    |August 13, 2016
    PubMed
    Summary

    Antenatal corticosteroid therapy is recommended for women at risk of premature birth. However, its benefits after 34 weeks of gestation remain under discussion.

    Area of Science:

    • Obstetrics and Gynecology
    • Neonatal Medicine
    • Pharmacology

    Context:

    • Premature birth presents significant risks to neonates.
    • Antenatal corticosteroid (ACS) administration is a key intervention to improve neonatal outcomes.
    • Evidence regarding the efficacy and safety of ACS after 34 weeks of gestation is evolving.

    Purpose:

    • To review and synthesize current evidence on the antenatal use of corticosteroids in the context of premature birth.
    • To critically evaluate the benefits and risks of corticosteroid administration between 34 and 37 weeks of gestation.
    • To inform clinical practice guidelines and future research directions.

    Summary:

    • Current evidence supports the use of antenatal corticosteroids for women at risk of preterm birth before 34 weeks gestation.

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  • The benefits of antenatal corticosteroids in women at risk of preterm birth after 34 weeks gestation are less clear and subject to ongoing debate.
  • Further research is needed to establish optimal timing and protocols for corticosteroid use in late preterm infants.

    • Impact:

    • Provides a comprehensive overview of the current evidence base for antenatal corticosteroid use.
    • Highlights areas of uncertainty and controversy, particularly for late preterm births.
    • Aims to guide clinical decision-making and resource allocation in perinatal care.