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Metyrapone decreases the glutathione concentration in liver and kidney
1Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, GDR.
Biomedica Biochimica Acta
|January 1, 1989
Abstract:
A single dose of 7.5 mg/100 g b.wt. metyrapone, intraperitoneally, decreased the concentration of reduced (GSH) and oxidized (GSSG) glutathione in the liver and kidney of female Wistar rats for approximately 4-5 h. The ratio between GSSG and GSH was not affected in the kidney but is decreased in the liver.