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Updated: Mar 16, 2026

Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
Progression of Heterotopic Ossification around the Elbow after Trauma
Dirk P Ter Meulen1, Sjoerd P F T Nota1, Michiel G J S Hageman1
1Dell Medical School, The University of Texas at Austin, Austin, USA.
Background:
This study addresses the null hypothesis that there is no expansion of heterotopic ossification (HO) in the elbow beyond what can be seen early on.
Methods:
The area of HO was measured on lateral radiographs of 38 consecutive patients that had operative treatment of HO between 2000 and 2013. Measurements from radiographs obtained between 3 to 7 weeks were compared to measurements from radiographs made 3 months or more after injury.
Results:
There was no significant difference between the average area of HO on the first (median 2.8 square centimeters, Q1: 1.5, Q3: 5.1) and later radiographs (median of 2.8 square centimeters, Q1: 1.4, Q3: 5.0) (P = 0.99).
Conclusion:
According to our results the area of HO does not expand beyond what can be seen early in the disease process.
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