Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Mar 16, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

18.9K

Nelumbinis Semen reverses a decrease in 5-HT1A receptor binding induced by chronic mild stress, a depression-like

Choon-Gon Jang1, Moonkyu Kang1,2, Jae-Han Cho1

  • 1Department of Pharmacology, College of Pharmacy, Sungkyunkwan University, 440-746, Suwon, Korea.

Archives of Pharmacal Research
|August 13, 2016
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TRPA1 antagonism reveals sex-specific mechanisms in morphine withdrawal-induced negative emotional behavior via dopaminergic pathway.

Neuropharmacology·2026
Same author

STAT6 inhibition of M2 macrophages suppresses tumor growth by modulating the tumor microenvironment in colon cancer model.

Frontiers in immunology·2026
Same author

Thiazole-Linked <i>N</i>-Hydroxypropanamide Derivatives: Selective HDAC6 Inhibitors with Therapeutic Potential for Neurodegenerative Diseases.

Journal of medicinal chemistry·2026
Same author

Structure-Activity Relationships and Ligand-Dependent Arrestin Bias in μ-Opioid Receptor-Mediated ERK Activation.

Biomolecules & therapeutics·2026
Same author

CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages.

NPJ precision oncology·2026
Same author

Comparative Evaluation of Disinfectants for Controlling <i>Listeria monocytogenes</i> on <i>Flammulina Velutipes</i>.

Mycobiology·2026

Nelumbinis Semen (N. s.) demonstrates antidepressant effects by reversing decreased serotonin 5-HT1A receptor binding in rats. This study investigated N. s. alongside St. John's Wort and fluoxetine for depression treatment.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Traditional Medicine

Background:

  • Depression is linked to serotonin (5-hydroxytryptamine; 5-HT) system dysfunction.
  • Reduced 5-HT1A receptor function and expression are implicated in depression development.
  • Chronic mild stress (CMS) is a model for inducing depression-like symptoms in rats.

Purpose of the Study:

  • To evaluate the antidepressant effect of Nelumbinis Semen (N. s.) in a rat model of depression.
  • To investigate if N. s. reverses CMS-induced decreases in 5-HT1A receptor binding.
  • To compare the efficacy of N. s. with Hypericum Perforatum (St. John's Wort) and fluoxetine.

Main Methods:

  • Rats were subjected to 8 weeks of CMS, with treatments administered during the final 4 weeks.
Keywords:
5-HT1A receptorAnti-depressionChronic mild stressDysfunctional 5-HT systemNelumbinis Semen

More Related Videos

Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

3.8K
Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
06:08

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

9.8K

Related Experiment Videos

Last Updated: Mar 16, 2026

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
07:13

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice

Published on: October 24, 2018

18.9K
Restraint to Induce Stress in Mice and Rats
03:48

Restraint to Induce Stress in Mice and Rats

Published on: December 6, 2024

3.8K
Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice
06:08

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

9.8K
  • Groups included: normal, CMS control, N. s. treatment, H. p. treatment, and fluoxetine treatment.
  • Sucrose intake test assessed antidepressant effects; 5-HT1A receptor binding assay (using 8-OH-DPAT) measured receptor changes in the hippocampus, frontal cortex, and hypothalamus.

    • Main Results:

    • N. s. significantly reversed CMS-induced decreases in sucrose intake.
    • Both N. s. and H. p. reversed CMS-induced decreases in 5-HT1A receptor binding in the hippocampus and frontal cortex.
    • N. s. and H. p. showed greater increases in frontal cortex 5-HT1A binding than fluoxetine; all treatments normalized binding in the hypothalamus.

    Conclusions:

    • Nelumbinis Semen exhibits antidepressant properties by enhancing 5-HT1A receptor binding.
    • The mechanism of N. s. is comparable to H. p. in modulating 5-HT1A receptor binding, differing from fluoxetine.
    • N. s. represents a potential therapeutic agent for depression through its effects on the serotonin system.