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Related Concept Videos

Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

896
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
896
Esophageal Perforation-I: Introduction01:22

Esophageal Perforation-I: Introduction

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Esophageal perforation is a severe medical condition characterized by a breach in the integrity of the esophageal wall. This breach can occur due to various factors such as trauma, medical procedures, or underlying diseases. When the esophageal wall is compromised, it allows food, fluids, and digestive juices into the chest cavity or adjacent structures, leading to potential complications and health risks.
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
719

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Related Experiment Video

Updated: Mar 16, 2026

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis
09:11

In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

Published on: June 8, 2022

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Necrotizing enterocolitis.

S F Calahane1, B Moore1

  • 1Department of Pathology, Children's Hospital, Temple Street, Dublin.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

Necrotizing enterocolitis (NEC) is a serious infant condition requiring awareness. Prompt intervention is crucial, and NEC may affect adults, resembling ischemic colitis.

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Last Updated: Mar 16, 2026

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Area of Science:

  • Pediatrics
  • Gastroenterology
  • Neonatology

Background:

  • Necrotizing enterocolitis (NEC) is a potentially fatal condition in infants with increasing incidence.
  • Early recognition and prompt management are critical for improving outcomes.

Purpose of the Study:

  • To present the clinical and pathological features of ten infants diagnosed with NEC.
  • To emphasize the diagnostic challenges and the importance of early intervention.

Main Methods:

  • Review of clinical and pathological data from ten infants with NEC.
  • Analysis of diagnostic signs, particularly radiological findings.
  • Evaluation of the role of shock in NEC pathogenesis.

Main Results:

  • Radiological signs for NEC diagnosis were found to be unreliable.
  • Evidence supports shock as a primary factor in NEC development.
  • Prompt intervention is essential for managing NEC.

Conclusions:

  • NEC is not exclusively a neonatal condition.
  • NEC in infants may be pathologically identical to ischemic colitis in adults.
  • Treatment strategies for NEC require careful consideration.