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Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
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Gastric function in primary hyperparathyroidism in man.

M G McGeown1,2, A M Connell1,2

  • 1The Renal Unit, Belfast City Hospital, Belfast.

Irish Journal of Medical Science
|August 13, 2016
PubMed
Summary
This summary is machine-generated.

Primary hyperparathyroidism patients often experience dyspepsia and duodenal ulcers. However, this study found no significant increase in gastric acid secretion in these patients, despite their gastrointestinal symptoms.

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Area of Science:

  • Gastroenterology
  • Endocrinology
  • Surgical Research

Background:

  • Primary hyperparathyroidism is associated with gastrointestinal disturbances.
  • The relationship between hyperparathyroidism and gastric function, particularly acid secretion, requires further elucidation.

Purpose of the Study:

  • To investigate gastric function in patients with primary hyperparathyroidism.
  • To assess the prevalence of dyspepsia and duodenal ulcers in this patient cohort.
  • To correlate gastric acid secretion levels with hyperparathyroidism status.

Main Methods:

  • Pre-operative assessment of gastric function in 55 primary hyperparathyroidism patients.
  • Barium meal examinations to identify duodenal ulcers.
  • Kay's augmented histamine test to measure gastric acid secretion.
  • Assays for antigastric-parietal-cell antibodies and serum gastrin levels.

Main Results:

  • 38% of patients reported dyspepsia, and 22% had duodenal ulcers, with higher incidence in males.
  • Gastric acid secretion levels were comparable to euparathyroid controls; no significant hyperchlorhydria was observed.
  • Antigastric-parietal-cell and antithyroid antibodies were absent.
  • Serum gastrin was slightly elevated pre-operatively in a minority of patients, with no consistent post-parathyroidectomy changes.

Conclusions:

  • Patients with primary hyperparathyroidism exhibit a high incidence of dyspepsia and duodenal ulcers.
  • Despite these symptoms, gastric acid secretion is not significantly elevated in primary hyperparathyroidism.
  • The pathogenesis of gastrointestinal symptoms in primary hyperparathyroidism may not be directly related to increased gastric acid production.