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Radiotherapy and Immunotherapy Combinations in Non-small Cell Lung Cancer: A Promising Future?

G G Hanna1, T Illidge2

  • 1Centre for Cancer Research and Cell Biology, Queen's University of Belfast, Belfast, UK.

Clinical Oncology (Royal College of Radiologists (Great Britain))
|August 14, 2016
PubMed

Insights

Harnessing the immune system to fight cancer, particularly non-small cell lung cancer, is now a reality. Immune checkpoint inhibitors and radiotherapy combinations show promise for durable anti-tumour responses.

Area of Science:

  • Oncology
  • Immunology
  • Radiotherapy

Background:

  • Reprogramming the host immune system to target malignancy has been a long-standing goal in cancer research.
  • Recent advancements have seen immune checkpoint inhibitors achieve unprecedented durable responses in solid tumours.

Purpose of the Study:

  • To review the mechanism of action of immune modulating agents.
  • To explore the potential of combining immune checkpoint inhibitors with radiotherapy for non-small cell lung cancer treatment.

Main Methods:

  • Literature review of immune checkpoint inhibitors.
  • Analysis of combination therapy potential with radiotherapy.

Main Results:

  • Immune checkpoint inhibitors have demonstrated significant efficacy in solid tumours.
  • Combination of immunotherapy and radiotherapy presents a promising strategy for non-small cell lung cancer.

Conclusions:

  • Immune checkpoint inhibitors have translated decades of speculation into clinical reality.
  • Combining immunotherapy with radiotherapy offers a potential new avenue for treating non-small cell lung cancer.
Keywords:
Checkpoint inhibitionNSCLCimmunotherapyradiotherapy

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