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Mild cognitive impairment and risk of depression and anxiety: A population-based study

Saira Saeed Mirza1, M Arfan Ikram2, Daniel Bos3

  • 1Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|August 14, 2016
PubMed
Abstract

Insights

Mild cognitive impairment (MCI) is a risk factor for developing depression and anxiety disorders. This study found individuals with MCI had higher rates of these conditions and an increased risk of developing them in the future.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Epidemiology

Background:

  • Mild cognitive impairment (MCI) often co-occurs with depression and anxiety.
  • The relationship between MCI and the future risk of developing these mental health conditions is not well understood.

Purpose of the Study:

  • To investigate the association between MCI and the prevalence and incidence of depressive and anxiety disorders.
  • To determine if MCI increases the risk of future depression or anxiety.

Main Methods:

  • The Rotterdam Study utilized cross-sectional and longitudinal data from 2002-2011.
  • Prevalence and incidence of Diagnostic and Statistical Manual of Mental Disorders-defined depressive and anxiety disorders were assessed in individuals with and without MCI.

Main Results:

  • Individuals with MCI had a higher prevalence of depressive and anxiety disorders at baseline.
  • Longitudinal analysis revealed that MCI significantly increased the risk of developing a depressive disorder (OR 3.13) and an anxiety disorder (OR 2.59).

Conclusions:

  • Mild cognitive impairment is identified as a risk factor for both dementia and psychiatric disorders, including depression and anxiety.
  • These findings suggest shared underlying pathological mechanisms for cognitive decline and mental health conditions.
Keywords:
AnxietyDepressionEpidemiologyLongitudinalMild cognitive impairmentPopulation based

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