Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms
02:34

Author Spotlight: Efficacy of Auricular Pressure Bean Therapy in Reducing Wheezing Symptoms

Published on: May 10, 2024

2.1K

Nonsteroidal anti-inflammatory drug administration in children with history of wheeze

Kendra Sih, Ran D Goldman

    Canadian Family Physician Medecin De Famille Canadien
    |August 14, 2016
    PubMed

    Insights

    Nonsteroidal anti-inflammatory drugs (NSAIDs) can be safely given to children with asthma, even those who wheeze, unless they have a history of NSAID-exacerbated respiratory disease (NERD). NSAIDs are effective pain relievers for children.

    Area of Science:

    • Pediatric Pharmacology
    • Allergy and Immunology

    Background:

    • Asthma is a common condition in children.
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently used for pain and fever.
    • Concerns exist regarding NSAID use in children with asthma due to potential respiratory reactions.

    Purpose of the Study:

    • To determine if asthma is a contraindication for NSAID use in children.
    • To investigate the existence and prevalence of NSAID-exacerbated respiratory disease (NERD) in pediatric populations.

    Main Methods:

    • Literature review on NSAID use in pediatric asthma.
    • Analysis of case reports and studies on NSAID-exacerbated respiratory disease (NERD).

    Main Results:

    • NSAIDs are effective analgesics and antipyretics.
    • NSAID-exacerbated respiratory disease (NERD) is well-documented in adults but not clearly described in a large number of children.
    • No clear contraindication for NSAID use in children with asthma exists unless a history of NERD is present.

    Conclusions:

    • NSAIDs can be recommended for children with known wheeze and asthma.
    • Caution is advised for children with a prior history of NSAID-exacerbated respiratory disease (NERD).
    • Asthma itself is not an absolute contraindication to NSAID administration in children.
    Abstract

    More Related Videos

    Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma14:39

    Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

    Published on: November 4, 2010

    32.6K
    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System07:28

    Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

    Published on: April 6, 2017

    41.7K

    Related Concept Videos

    Asthma-IV: Diagnostic and Management01:30

    Asthma-IV: Diagnostic and Management

    The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
    Clinical Assessment for Asthma:
    This is the first step in diagnosing and managing asthma. It includes:
    3.3K
    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

    Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

    Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
    Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
    2.2K
    Antiasthma Drugs: Leukotriene Modifiers01:19

    Antiasthma Drugs: Leukotriene Modifiers

    Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
    Leukotriene modifiers work through two distinct mechanisms:
    2.2K
    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

    Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

    Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
    ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
    1.8K
    Inhaled Medications01:23

    Inhaled Medications

    Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
    959
    Antiasthma Drugs: β2-Adrenoceptor Agonists01:25

    Antiasthma Drugs: β2-Adrenoceptor Agonists

    Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
    One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce...
    1.9K