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    Area of Science:

    • Nuclear Medicine
    • Radiology
    • Diagnostic Imaging

    Background:

    • Skeletal scintigraphy using technetium-99m pyrophosphate (99mTc-PYP) is primarily used for bone imaging.
    • Extraosseous uptake can occur but its diagnostic significance is not always well-defined.

    Purpose of the Study:

    • To determine the frequency, patterns, and diagnostic importance of extraosseous soft tissue findings on 99mTc-PYP skeletal scintigraphy.
    • To evaluate the role of SPECT/CT in characterizing these findings.

    Main Methods:

    • Retrospective analysis of 1060 patients undergoing 99mTc-PYP skeletal scintigraphy.
    • Whole-body planar imaging and SPECT/CT when indicated.
    • Categorization of extraosseous findings into nephrourological, soft tissue, and artifactual.

    Main Results:

    • Extraosseous findings were identified in 15.2% of patients.
    • Nephrourological (7.7%) and soft tissue (5.4%) abnormalities were most common.
    • Pathologic soft tissue findings included breast cancer, testicular cancer, and nodular goiter, confirmed by clinical data.

    Conclusions:

    • Abnormal extraosseous findings on 99mTc-PYP scintigraphy provide valuable diagnostic information.
    • Interpretation of these findings can significantly impact patient management and treatment strategies.