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Updated: Mar 16, 2026

Generation of Human Brain Organoids for Mitochondrial Disease Modeling
Published on: June 21, 2021
The enduring legacy of pioneering neuroscientist Dr. Jerzy Edwin Rose
Jordan T Gaal1, Matthew Stenerson1, John S Kuo1
1Department of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4/8 CSC, Box 8660, Madison, WI 53792, United States.
Abstract:
The human nervous system maintains dominion over everything experienced in life, consolidating a constant barrage of stimuli and chemical fluctuation into memory, sense, emotion, and even character. Despite decades of productive investigation, comprehension of the nervous system's function and structure remain shrouded in mystery. Historically, the burden of elucidating these mysteries has fallen to neuroscientists bold enough to seek answers to this most nebulous vista. The legacy of one such neuroscientist, Jerzy Edwin Rose, endures today as a pillar of neuroscientific discovery. In the nascence of his career, Rose explored volumetric comparisons of human brain structure to that of other mammals, leading to the development of novel methods in neurophysiologic measurement and explanation. Rose would later segue mid-career into studies on the cooperation between the auditory cortex and thalamus, resulting in increased understanding of its functioning, structure, and anatomy. During the final saga of his long, fruitful career, Rose explored the electrophysiology of the auditory system, leading to novel methods using modern technology. Ultimately, the vast breadth of Rose's contributions to neuroscience has diminished the field's mystery, setting forth momentous groundwork for future discovery, and the inspiration to carry on in the spirit of his bold curiosity.
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