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Identification of Rare Bacterial Pathogens by 16S rRNA Gene Sequencing and MALDI-TOF MS
Published on: July 11, 2016
Aggregatibacter aphrophilus misidentified as Brucella spp. in an immunocompetent patient with brain abscess
Ahmet Cagkan Inkaya1, Salih Macin2, Gokhan Bozkurt3
1Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Sihhiye, Ankara, Turkey.
Abstract:
Aggregatibacter aphrophilus rarely causes brain abscesses. Here we report a case of the brain abscess caused by Aggregatibacter aphrophilus. Cultivated gram negative coccobacilli from cerebral abscess were initially misidentified as Brucella spp. because it gave false positive agglutination with anti-Brucella sera. Definite identification was made with MALDI-TOF assay. Right to left shunt through the pulmonary arteriovenous malformation was speculated to be the underlying cause for the brain abscess. The patient was treated successfully with ampicillin-sulbactam after failing ceftriaxone treatment.
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