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Multiple Circulating Cytokines Are Coelevated in Chronic Obstructive Pulmonary Disease
Senthooran Selvarajah1, Ian Todd1, Patrick J Tighe1
1School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK.
Mediators of Inflammation
|August 16, 2016
Summary
Certain cytokines like TNFα and IL-1β indicate significant systemic inflammation in COPD. Numerous cytokines together, not individually, correlate with COPD severity, reflecting the disease
Area of Science:
- Pulmonary Medicine
- Immunology
- Biomarker Discovery
Background:
- Chronic Obstructive Pulmonary Disease (COPD) involves systemic inflammation.
- The role of specific circulating cytokines in COPD-related systemic pathology needs clarification.
Purpose of the Study:
- To investigate the association between specific circulating cytokines and systemic pathology in COPD.
- To identify potential cytokine biomarkers for COPD severity and systemic inflammation.
Main Methods:
- Development of a protein microarray system for multiplex cytokine detection.
- Measurement of fourteen cytokines in serum from healthy controls (never-smokers) and COPD patients (GOLD stages 1-3).
Main Results:
- Elevated levels of individual cytokines, notably TNFα and IL-1β, were observed in some COPD patients and smokers without COPD, suggesting systemic inflammation.
- A combined elevation of numerous cytokines, rather than individual ones, significantly correlated with COPD disease severity.
- These findings indicate a complex inflammatory profile in COPD.
Conclusions:
- Specific cytokines can serve as markers for significant systemic inflammation in COPD.
- The collective elevation of multiple cytokines is a stronger indicator of COPD severity and systemic involvement.
- This highlights the chronic, systemic nature of COPD and its associated comorbidities.
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