Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Thermoregulation

Thermoregulation

The human body has a sophisticated thermoregulation system that employs negative feedback mechanisms to maintain an optimal core temperature. When the core temperature drops, peripheral and central thermoreceptors send signals to the hypothalamus, activating the heat-promoting center. This center triggers several responses aimed at increasing the core temperature. First, vasoconstriction reduces the flow of warm blood from internal organs to the skin so that the heat is not lost from the skin,...

Physiological Control of Respiration

Physiological Control of Respiration

Introduction
Breathing, a seemingly passive process, is regulated by the respiratory center in the brainstem. This center coordinates the involuntary control of respirations, which means it occurs without conscious effort, ensuring a smooth and uninterrupted pattern.
Regulation of Ventilation
The body maintains ventilation by monitoring levels of carbon dioxide (CO2), oxygen (O2), and hydrogen ion concentration (pH) in the arterial blood. Among these factors, the level of CO2 plays a crucial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Intrinsic capacity and mortality in community-dwelling octogenarians: a network analysis from the ilSIRENTE study.

GeroScience·2026

Same author

The Gut-Muscle Axis in Sarcopenia: Mechanisms, Evidence Gaps and Translational Challenges.

Biomedicines·2026

Same author

Feasibility of home-based, remotely delivered exercise training to improve physical function in older sepsis survivors: a pilot randomized controlled trial.

GeroScience·2026

Same author

Mullerian adenosarcoma of the uterus, ovary and peritoneum: Whole transcriptomic digital spatial profiling (DSP) in a cohort of 42 tumors.

Human pathology·2026

Same author

Iron dysregulation and mitochondrial dysfunction in aging: A longitudinal study on mobility decline in low- and high-functioning older adults.

Experimental gerontology·2026

Same author

Circulating cellular senescence biomarkers in persons with chronic knee osteoarthritis pain: An exploratory study.

Molecular pain·2026

Search research articles

Related Experiment Video

Updated: Mar 16, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Integrated control of brown adipose tissue.

Emanuele Marzetti¹, Emanuela D'Angelo¹, Giulia Savera¹

¹Department of Geriatrics, Neurosciences and Orthopedics, Teaching Hospital "Agostino Gemelli", Rome, Italy.

Heart and Metabolism : Management of the Coronary Patient

|August 16, 2016

Summary

Brown adipose tissue (BAT) and beige/brite cells generate heat, offering potential for obesity and metabolic disease treatment. Understanding their complex regulation is key to developing effective therapies targeting these thermogenic tissues.

Keywords:

adipokines adiposity beige cells bone morphogenetic protein (BMP)brite adipose tissue brown adipose tissue (BAT)cold exposure diabetes mellitus energy metabolism fibroblast growth factor (FGF)inflammation insulin resistance mitochondrial respiration natriuretic peptide obesity positron emission tomography (PET)sympathicomimetics thermogenesis thermoregulation thyroid hormone receptor thyroid hormones uncoupling protein uncoupling protein (UCP)weight loss white adipose tissue (WAT)

More Related Videos

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

Related Experiment Videos

Last Updated: Mar 16, 2026

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Differentiation and Imaging of Brown Adipocytes from the Stromal Vascular Fraction of Interscapular Adipose Tissue from Newborn Mice

Published on: February 3, 2023

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Isolation and Differentiation of Stromal Vascular Cells to Beige/Brite Cells

Published on: March 28, 2013

Area of Science:

Metabolic physiology
Adipose tissue biology
Thermoregulation

Background:

Brown adipose tissue (BAT) is a thermogenic organ crucial for heat production in mammals.
Metabolically active BAT and beige/brite cells are found in adult humans, offering therapeutic potential.
Thermogenic adipose tissues act as metabolic sinks for glucose and lipids.

Purpose of the Study:

To review the regulation of brown and brite adipose tissue function.
To discuss the therapeutic potential of targeting these tissues for metabolic disorders.
To highlight the challenges in developing therapies due to complex interorgan regulation.

Main Methods:

Literature review of current knowledge on BAT and brite cell regulation.
Analysis of the role of thermogenic adipose tissue in energy metabolism.
Discussion of therapeutic strategies targeting adipose tissue.

Main Results:

BAT and beige/brite cells dissipate metabolic energy as heat.
These tissues play a significant role in glucose and lipid metabolism.
Complex interorgan networks regulate BAT and brite tissue mass and function.

Conclusions:

Targeting BAT and brite adipose tissues holds promise for treating obesity and metabolic diseases.
Further research into the intricate regulatory networks is essential for therapeutic development.
Understanding the function and regulation of thermogenic adipocytes is critical for metabolic health interventions.