Related Experiment Video
Updated: Mar 16, 2026

Measurement of Ultrafast Vibrational Coherences in Polyatomic Radical Cations with Strong-Field Adiabatic Ionization
Published on: August 6, 2018
Four Simultaneously Dynamic Covalent Reactions. Experimental Proof of Orthogonality
Helen M Seifert1, Karina Ramirez Trejo1, Eric V Anslyn1
1Department of Chemistry, University of Texas at Austin , Austin, Texas 78712, United States.
Abstract:
Dynamic covalent reactions are widely used in dynamic combinatorial chemistry. Most of these reactions are run under differing reaction conditions and exhibit cross-reactivity when components of multiple reactions are present in one reaction vessel. Herein, we report the study of four dynamic covalent reactions that react reversibly under identical reaction conditions and do not exhibit any cross-reactivity. Dynamic behavior was shown via (1)H NMR based exchange experiments. Computational deconvolution of (1)H NMR spectra containing the components for more than one of the orthogonal reactions allowed for a semiquantitative analysis of the complex mixtures formed, showing that the reactions proceed independently of each other. Therefore, it is possible to use all four reactions in one pot in a simultaneous, yet orthogonal fashion. This opens up possibilities for the preprogrammed formation of complex thermodynamic assemblies.
More Related Videos
Related Concept Videos
Hybridization of Atomic Orbitals II
MO Theory and Covalent Bonding
Hybridization of Atomic Orbitals I
Diels–Alder vs Retro-Diels–Alder Reaction: Thermodynamic Factors
Cycloaddition Reactions: MO Requirements for Thermal Activation
Homogeneous Equilibria for Gaseous Reactions
For gas-phase reactions, the equilibrium constant may be expressed in terms of either the molar concentrations (Kc) or partial pressures (Kp) of the reactants and products. A relation between these two K values may be simply derived from the ideal gas equation and the definition of molarity. According to the ideal gas equation:

