Inhibitory effects of gossypol analogs on human sperm motility

¹Department of Obstetrics and Gynecology, Loeb Institute for Medical Research, Ottawa Civic Hospital, University of Ottawa, Ontario, Canada.

|June 1, 1989

Abstract:

Aqueous-soluble gossypol Schiff's bases, SP562: bis-8,8'-[(N-(2-(dimethylamino)ethyl]-iminomethylene]- [1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2- binaphthalene dihydrochloride; SP563: bis-8,8'-[(N-(2-(diethylamino)ethyl]-iminomethylene]-1,1',6,6',7,7 '- hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene++ + dihydrochloride; and SP564: bis-8,8'-[(N-(2-(diethylamino)propyl]-iminomethylene]- 1,1',6,6',7,7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'- binaphthalene dihydrochloride, were investigated for their effects on human sperm motility. SP564, which has the longest alkyl substituent of the Schiff's base, appeared to exert the greatest inhibitory effects on human sperm motility. These inhibitory effects were even greater than those caused by (+/-)gossypol acetic acid at the same concentration.

Keywords:

Biology Contraception Contraceptive Agents, Male--side effects Contraceptive Agents--side effects Contraceptive Mode Of Action Examinations And Diagnoses Family Planning Genitalia Genitalia, Male Gossypol--side effects Inhibition Of Fertilization Laboratory Examinations And Diagnoses Physiology Semen--analysis Seminal Vesicles Sperm Transport Inhibition Urogenital System

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