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Updated: Mar 16, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Platelet concentrate functionality assessed by thromboelastography or rotational thromboelastometry.

Ahmad F Arbaeen1,2, Katherine Serrano1,3, Elena Levin1,3

  • 1Department of Pathology and Laboratory Medicine and Centre for Blood Research, University of British Columbia, Vancouver, British Columbia, Canada.

Transfusion
|August 17, 2016
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Summary

Thromboelastography (TEG) can assess platelet concentrate (PC) quality and distinguish responsive from nonresponsive PCs. This method also quantizes platelet microvesicles (PMVs) contribution to clot formation.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Biomaterials Science

Background:

  • Standard in vitro tests poorly correlate with in vivo platelet concentrate (PC) transfusion outcomes.
  • Current tests assess platelet (PLT) characteristics, not functional effectiveness.
  • Platelet microvesicles (PMVs) may influence clot formation and transfusion efficacy.

Purpose of the Study:

  • To evaluate thromboelastography (TEG) for assessing stored PLT quality.
  • To determine if TEG can distinguish between hyper- and nonresponsive PCs.
  • To investigate the contribution of PMVs to TEG clot signatures.

Main Methods:

  • Validated TEG assays for buffy coat PCs.
  • Assessed PCs during storage and after reconstitution with plasma.
  • Generated poor-quality PCs for comparative analysis.
  • Evaluated PMV contribution to TEG clot signature.

Main Results:

  • TEG showed no significant change in maximum amplitude (MA) for PCs up to Day 10.
  • Poor quality PCs on Day 8 showed a significant decrease in MA.
  • PMV-rich samples significantly increased MA; PMV count correlated with clot formation (r=0.51, p<0.01).

Conclusions:

  • TEG is sensitive to poor PC storage conditions but lacks sensitivity for normal storage changes.
  • TEG can dissect PLT and PMV contributions to clot formation.
  • TEG shows promise for assessing PC quality and predicting transfusion outcomes.