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Updated: Mar 16, 2026
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
Published on: September 27, 2013
Advanced nanostructured medical device combining mesenchymal cells and VEGF nanoparticles for enhanced engineered
Quentin Wagner1,2, Damien Offner1,2, Ysia Idoux-Gillet1,2
1INSERM (French National Institute of Health & Medical Research), "Osteoarticular & Dental Regenerative Nanomedicine" Laboratory, UMR 1109, Faculté de Médecine, F-67085 Strasbourg Cedex. FMTS, France.
Aim:
Success of functional vascularized tissue repair depends on vascular support system supply and still remains challenging. Our objective was to develop a nanoactive implant enhancing endothelial cell activity, particularly for bone tissue engineering in the regenerative medicine field.
Materials & Methods:
We developed a new strategy of tridimensional implant based on cell-dependent sustained release of VEGF nanoparticles. These nanoparticles were homogeneously distributed within nanoreservoirs onto the porous scaffold, with quicker reorganization of endothelial cells. Moreover, the activity of this active smart implant on cells was also modulated by addition of osteoblastic cells.
Results & Conclusion:
This sophisticated active strategy should potentiate efficiency of current therapeutic implants for bone repair, avoiding the need for bone substitutes.
