Related Experiment Video
Updated: Mar 16, 2026
09:57
Isolation and Analysis of Traceable and Functionalized Extracellular Vesicles from the Plasma and Solid Tissues
Published on: October 17, 2022
2.9K
Telocytes and Their Extracellular Vesicles-Evidence and Hypotheses.
Dragos Cretoiu1,2, Jiahong Xu3, Junjie Xiao4
1Division of Cellular and Molecular Biology and Histology, Department of Morphological Sciences, Carol Davila University of Medicine and Pharmacy, Bucharest 050474, Romania. dragos@cretoiu.ro.
International Journal of Molecular Sciences
|August 17, 2016
Summary
Telocytes (TCs), a novel interstitial cell type, communicate via direct junctions and extracellular vesicles (EVs). Research explores their potential regenerative role and EV release mechanisms.
Area of Science:
- Cell Biology
- Histology
- Regenerative Medicine
Background:
- Telocytes (TCs) represent a recently discovered type of interstitial cell.
- These cells are found ubiquitously within the extracellular matrix of various tissues.
- TCs possess unique telopodes structures involved in intercellular communication.
Purpose of the Study:
- To review existing evidence on extracellular vesicle (EV) release by telocytes (TCs).
- To discuss the potential implications of TCs and their EVs in regenerative medicine.
- To present alternative hypotheses regarding the future role of TCs.
Main Methods:
- Literature review of studies investigating telocytes (TCs).
- Analysis of evidence supporting EV release from TCs.
- Discussion of theoretical implications based on current research.
Main Results:
- Telocytes (TCs) are confirmed to release extracellular vesicles (EVs).
- Evidence suggests TCs play a role in intercellular communication through EVs.
- The regenerative potential of TCs is an active area of investigation.
Conclusions:
- Telocytes (TCs) are significant interstitial cells with a role in intercellular communication via EVs.
- Further research is needed to fully understand the regenerative capabilities and therapeutic applications of TCs and their EVs.
More Related Videos
Related Concept Videos
01:45Vesicular Tubular Clusters
3.3K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
With the help of motor proteins such...
3.3K
01:36Overview of Exosomes
3.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
3.9K
01:33Overview of Secretory Vesicles
9.8K
Secretory vesicles, also known as dense core vesicles (DCVs), are membrane-bound vesicles that transport secretory proteins, such as hormones or neurotransmitters. Regulated secretory vesicles transport proteins from the trans-Golgi network to the exterior of the cell. Proteins present in regulated secretory vesicles are required to be rapidly exocytosed in large amounts upon a specific stimulus.
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
9.8K
01:26Transport Across the Golgi
6.5K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
6.5K
01:38Intralumenal Vesicles and Multivesicular Bodies
5.1K
Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
5.1K
01:44Introduction to Membrane Traffic
10.1K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
10.1K