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Related Concept Videos

Brain Imaging01:14

Brain Imaging

886
Brain imaging technologies provide critical insights into both the structure and function of the human brain, enabling medical professionals and researchers to diagnose, study, and treat neurological disorders or psychiatric disorders more effectively.
These technologies include computerized axial tomography (CAT or CT scans), positron-emission tomography (PET scans),  magnetic resonance imaging (MRI),  functional magnetic resonance imaging (fMRI), and Transcranial Magnetic...
886

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Suitable reference tissues for quantitative susceptibility mapping of the brain.

Sina Straub1, Till M Schneider2,3, Julian Emmerich1

  • 1Department of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Magnetic Resonance in Medicine
|August 17, 2016
PubMed
Summary

For quantitative susceptibility mapping (QSM) of the brain, cerebrospinal fluid (CSF) and the internal capsule are identified as the most stable reference tissues. These regions show minimal variation across patients and are independent of age or disease stage.

Keywords:
age dependencebrainmalignant melanomametastasisquantitative susceptibility mappingreference

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Radiology

Background:

  • Quantitative susceptibility mapping (QSM) requires a stable reference tissue for accurate magnetic susceptibility measurements.
  • Comparing QSM across subjects and disease states necessitates reliable reference regions.

Purpose of the Study:

  • To identify suitable reference tissues for brain QSM.
  • To evaluate the stability of various brain regions as QSM references in melanoma patients.

Main Methods:

  • Assessed susceptibility values in twelve reference regions across melanoma patients.
  • Analyzed stability concerning intra-individual and inter-individual variability, age, and disease stage.

Main Results:

  • Cerebrospinal fluid (CSF) and the internal capsule demonstrated the smallest standard deviations in mean susceptibility values.
  • CSF and internal capsule showed minimal dependence on age or disease stage, unlike other regions like the red nucleus.

Conclusions:

  • The internal capsule and CSF are recommended as the most suitable reference regions for brain QSM.
  • These regions offer stability and minimal dependence on patient-specific factors for QSM analysis.