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[Research advances of posterior reversible encephalopathy syndrome in children]
1Department of Pediatrics, Peking University People's Hospital, Beijing 100044, China. liujingdrm@163.com.
Insights
Posterior reversible encephalopathy syndrome (PRES) is a brain condition affecting the occipital and parietal lobes. Early diagnosis and treatment are crucial for recovery and preventing severe complications like hemorrhage or edema.
Area of Science:
- Neurology
- Radiology
Background:
- Posterior reversible encephalopathy syndrome (PRES) is a clinico-neuroradiological condition impacting the brain's posterior regions, specifically the occipital and parietal lobes.
- PRES symptoms include headaches, altered mental status, seizures, and visual disturbances.
Purpose of the Study:
- To summarize the key aspects of Posterior Reversible Encephalopathy Syndrome (PRES).
- To highlight the importance of early identification and treatment.
Main Methods:
- Review of existing literature on PRES.
- Analysis of clinical and radiological characteristics.
Main Results:
- PRES is characterized by specific neurological symptoms and posterior brain involvement.
- Endothelial dysfunction is a potential key factor in PRES pathogenesis.
- While often reversible, severe PRES can lead to significant morbidity and mortality.
Conclusions:
- Early identification and prompt, appropriate treatment are vital for managing PRES.
- Understanding the underlying causes and risk factors is essential for effective intervention.
Abstract:
Posterior reversible encephalopathy syndrome (PRES) is a clinico-neuroradiological entity affecting the posterior brain, i.e. occipital and parietal lobes. The syndrome are characterized by headaches, altered mental status, seizures, and visual disturbances. Although the pathogenesis remains unclear, endothelial dysfunction may be a key factor. The basic disease may play a crucial role in the incidence of PRES. In most cases, PRES resolves spontaneously and patients show both clinical and radiological improvements. In severe forms, PRES might cause substantial morbidity with sequel and even mortality, as a result of acute hemorrhage or massive posterior fossa edema causing obstructive hydrocephalus or brainstem compression. Early identification, active and appropriate treatment is very important.
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