Related Experiment Video
Updated: Feb 6, 2026

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
Published on: May 16, 2025
The 100 classic papers in ulcerative colitis: a bibliometric analysis
Tara M Connelly1, Liam Devane1, John C Kelly2
1a Department of Surgery , University Hospital Waterford , Waterford , Ireland.
Citation analysis reveals the most influential ulcerative colitis (UC) research. Key topics include genetics, treatment, and immunology, with US and UK researchers leading advancements in UC understanding and therapy.
Area of Science:
- Gastroenterology and Hepatology
- Immunology
- Genetics
Background:
- Citation analysis of top-cited papers offers insight into ulcerative colitis (UC) research progression.
- Identifies key advancements in disease understanding and treatment innovations over time.
Purpose of the Study:
- To identify and analyze the 100 most cited manuscripts in ulcerative colitis (UC) research.
- To understand the historical impact of specific topics, authors, and institutions in the field.
Main Methods:
- Utilized Thomson Reuters Web of Knowledge to identify the 100 most cited UC manuscripts.
- Analyzed publication details including title, authors, institutions, journal, country, year, and topic.
Main Results:
- The top 100 papers were published between 1955-2012, predominantly from the US (38%) and UK (26%).
- Genetics (27 papers), treatment (22 papers), and immunological pathways (17 papers) were the most frequent topics.
- Truelove was the most prolific author; St. Mark's, London and Radcliffe Infirmary led in institutional publications.
Conclusions:
- This compilation highlights impactful topics and authors in UC research over the past century.
- Serves as a reference for influential UC papers and defines characteristics of highly citable research for scientists and clinicians.
Related Concept Videos
Drugs for Treatment of Ulcerative Colitis in IBD
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Classical Conditioning
Ivan Pavlov observed that dogs...
Principles of Classical Conditioning
During the...
Classical Conditioning in Daily Life
John B. Watson and Rosalie Rayner famously demonstrated the development of fear through classical conditioning in their experiment with Little Albert. They paired the...
Peptic Ulcer Disease II: Pathophysiology
Damaging agents such as Helicobacter pylori, gastric acid, pepsin, and nonsteroidal anti-inflammatory drugs (NSAIDs) can weaken the mucosal defense, allowing hydrogen ions to infiltrate back and harm epithelial cells.

