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Isolation and structure of corazonin, a cardioactive peptide from the American cockroach
1Department of Biological Organic Chemistry, Centro de Investigación y Desarrollo, CSIC, Barcelona, Spain.
FEBS Letters
|July 3, 1989
Abstract:
Corazonin, a new cardioaccelerating peptide, has been isolated from the corpora cardiaca of the American cockroach, Periplaneta americana, and its structure determined to be Glp-Thr-Phe-Gln-Tyr-Ser-Arg-Gly-Trp-Thr-Asn-amide. The peptide stimulated heart beat at concentrations as low as 0.2 nM, which makes it the most potent insect cardioactive neuropeptide.