Aspergillus flavus SUMO Contributes to Fungal Virulence and Toxin Attributes
Xinyi Nie1, Song Yu1, Mengguang Qiu1
1Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province, Key Laboratory of Biopesticide and Chemical Biology of Education Ministry, School of Life Sciences, Fujian Agriculture and Forestry University , Fuzhou 350002, China.
Abstract:
Small ubiquitin-like modifiers (SUMOs) can be reversibly attached to target proteins in a process known as SUMOylation, and this process influences several important eukaryotic cell events. However, little is known regarding SUMO or SUMOylation in Aspergillus flavus. Here, we identified a novel member of the SUMO family in A. flavus, AfSumO, and validated the existence of SUMOylation in this pathogenic filamentous fungus. We investigated the roles of AfsumO in A. flavus by determining the effects of AfsumO mutations on the growth phenotype, stress response, conidia and sclerotia production, aflatoxin biosynthesis, and pathogenicity to seeds, and we found that SUMOylation plays a role in fungal virulence and toxin attributes. Taken together, these results not only reveal potential mechanisms of fungal virulence and toxin attributes in A. flavus but also provide a novel approach for promising new control strategies of this fungal pathogen.
Related Concept Videos
Fungal Phylum Ascomycota
Gene Regulation in Microbial Communities: Quorum Sensing
Fungal Group Zygomycota
Fungal Phylum Basidiomycota
Fungal Phylum Microsporidia
Conservative Site-specific Recombination and Phase Variation
The recognition sites for Cre recombinase called LoxP...


