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Related Experiment Video

Updated: Mar 16, 2026

How to Build a Laser Speckle Contrast Imaging LSCI System to Monitor Blood Flow
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Low-cost compact diffuse speckle contrast flowmeter using small laser diode and bare charge-coupled-device.

Chong Huang1, Myeongsu Seong2, Joshua Paul Morgan3

  • 1University of Kentucky, Department of Biomedical Engineering, 143 Graham Avenue, Lexington, Kentucky 40506, United States.

Journal of Biomedical Optics
|August 18, 2016
PubMed
Summary

A new low-cost diffuse speckle contrast flowmeter (DSCF) accurately measures blood flow variations in deep tissues. This compact device shows promise for monitoring blood flow changes in vascular diseases.

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Area of Science:

  • Biomedical Optics
  • Medical Devices
  • Physiological Monitoring

Background:

  • Accurate blood flow measurement is crucial for diagnosing and monitoring vascular diseases.
  • Existing methods for blood flow monitoring can be expensive, bulky, or limited in tissue depth penetration.

Purpose of the Study:

  • To develop and validate a low-cost, compact diffuse speckle contrast flowmeter (DSCF) for measuring blood flow variations.
  • To assess the performance of the DSCF against established methods in phantoms and in vivo.

Main Methods:

  • A novel DSCF device utilizing a laser diode and CCD chip for contact measurements up to ~8mm deep.
  • Comparison of DSCF measurements with noncontact diffuse speckle contrast spectroscopy and contact diffuse correlation spectroscopy.
  • Validation using tissue phantoms and human forearm measurements with Bland–Altman analysis.

Main Results:

  • The DSCF demonstrated good agreement with other methods, showing no significant bias.
  • Limits of agreement were 96.5%±2.2% in phantom experiments and 92.8% in forearm tests.
  • Slightly lower agreement in vivo may be attributed to tissue heterogeneity.

Conclusions:

  • The low-cost, compact DSCF is a viable tool for measuring blood flow variations in relatively deep tissues.
  • The device has significant potential for continuous, longitudinal monitoring of blood flow in ischemic/hypoxic tissues.
  • This technology could aid in the management of various vascular diseases.