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Rapid Molecular Detection and Differentiation of Influenza Viruses A and B
05:38

Rapid Molecular Detection and Differentiation of Influenza Viruses A and B

Published on: January 30, 2017

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Hospitalization for Influenza A Versus B

Dat Tran1, Wendy Vaudry2, Dorothy Moore3

  • 1Division of Infectious Diseases, Department of Paediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada; dat.tran@sickkids.ca.

Pediatrics
|August 19, 2016
PubMed

Insights

Pediatric influenza B infections led to higher mortality than influenza A. Older, healthy children with influenza B faced increased intensive care unit (ICU) admission risks.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Public Health Surveillance

Background:

  • The comparative clinical impact of influenza A and B in children is not well-defined.
  • Understanding differences is crucial for pediatric respiratory illness management and prevention strategies.

Purpose of the Study:

  • To compare clinical characteristics and outcomes of pediatric influenza A versus B hospitalizations.
  • To identify factors associated with intensive care unit (ICU) admission in children with influenza B.

Main Methods:

  • Utilized active surveillance data from the Canadian Immunization Monitoring Program Active (IMPA) across 12 pediatric hospitals.
  • Analyzed laboratory-confirmed influenza A and B cases in children aged 16 years or younger over 8 nonpandemic seasons (2004-2013).
  • Compared clinical presentations, outcomes, and risk factors for ICU admission.

Main Results:

  • 1510 influenza B and 2645 influenza A cases were identified; median ages differed significantly (3.9 vs 2.0 years).
  • Influenza B patients were more likely to have vaccine-indicated conditions and presented with headache, abdominal pain, and myalgia.
  • Mortality was significantly higher for influenza B (1.1%) compared to influenza A (0.4%), with adjusted odds ratios of 2.65 for influenza-attributed death and 2.95 for all-cause mortality.
  • Among healthy children with influenza B, those aged 10 years or older had a significantly higher risk of ICU admission (OR = 5.79).

Conclusions:

  • Pediatric influenza B infection is associated with greater mortality than influenza A.
  • Older, healthy children hospitalized with influenza B exhibit a significant risk for ICU admission.
Abstract

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