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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
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Drug Toxicity: Dose-Dependent Reactions01:24

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Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
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Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

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Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
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Drug Toxicity: Overview01:00

Drug Toxicity: Overview

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Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

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Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
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Drug toxicity: Idiosyncratic Reactions01:16

Drug toxicity: Idiosyncratic Reactions

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Idiosyncratic drug reactions represent abnormal chemical responses that vary significantly among individuals, ranging from extreme sensitivity to low doses to insensitivity to high doses. These reactions often occur due to the drug's covalent binding with serum proteins, forming a foreign hapten that triggers an immunotoxicological response. The variability in drug reactions has a strong pharmacogenetic foundation, with genetic differences crucial in how individuals metabolize drugs. For...
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Related Experiment Video

Updated: Mar 16, 2026

Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research
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Author Spotlight: Integrating Mechanical and Biological Analysis in Tendinopathy Research

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Drug-Induced Tendon Disorders.

Karsten Knobloch1

  • 1SportPraxis Prof. Knobloch, Heiligerstr. 3, Hannover, 30159, Germany. professor.knobloch@sportpraxis-knobloch.de.

Advances in Experimental Medicine and Biology
|August 19, 2016
PubMed
Summary
This summary is machine-generated.

Certain medications can harm tendons, leading to conditions like tendinopathy and rupture. Four drug classes—corticosteroids, fluoroquinolones, aromatase inhibitors, and statins—are linked to these adverse tendon effects.

Keywords:
Adverse effectAromatase inhibitorChinolonCorticosteroidStatinTendonTendon ruptureTreatment

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Biomechanical Testing of Murine Tendons
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Area of Science:

  • Orthopedics
  • Pharmacology
  • Sports Medicine

Background:

  • Drug-induced tendon disorders are an underrecognized clinical issue.
  • These disorders can manifest as tendinopathy or tendon rupture.
  • The Achilles tendon is most commonly affected, but other tendons can also be involved.

Purpose of the Study:

  • To review the known drug classes associated with tendon disorders.
  • To highlight the spectrum of tendon damage caused by medications.
  • To increase awareness among clinicians regarding this risk factor.

Main Methods:

  • Literature review of drug-induced tendon pathologies.
  • Identification of drug classes implicated in tendon damage.
  • Analysis of clinical presentations and affected tendons.

Main Results:

  • Four primary drug classes are associated with tendon issues: corticosteroids, fluoroquinolone antibiotics, aromatase inhibitors, and statins (HMG-CoA-reductase inhibitors).
  • These agents can negatively impact tendon properties, increasing risks of injury.
  • While the Achilles tendon is frequently involved, any tendon can be affected.

Conclusions:

  • Healthcare providers should consider drug-induced tendon pathology in patients presenting with tendon problems.
  • Awareness of these medication risks is crucial for prevention and timely management.
  • Further research may elucidate specific mechanisms and identify at-risk populations.