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Drug Delivery by Controlling a Supramolecular Host-Guest Assembly with a Reversible Photoswitch

Nuno Basílio1, Uwe Pischel2

  • 1Laboratório Associado para a Química Verde (LAQV), Rede de Química e Tecnologia (REQUIMTE), Departmento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, 2829-516, Caparica, Portugal. nuno.basilio@fct.unl.pt.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|August 19, 2016
PubMed

Keywords:
cucurbiturilsdrug deliveryflavyliumhost-guest chemistryphotochemistry

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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also...
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