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Hürthle cell neoplasm.

L A Marzano1, L Finelli, A Marranzini

  • 1Dipartimento di Patologia Sistemica, II Facoltà di Medicina e Chirurgia, Università di Napoli, Italy.

International Surgery
|April 1, 1989
PubMed
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Hürthle cell neoplasms (HNC) are uncommon thyroid tumors. Initial treatment involves hemithyroidectomy, with total thyroidectomy reserved for confirmed malignancy.

Area of Science:

  • Endocrinology
  • Surgical Oncology
  • Pathology

Background:

  • Hürthle cell neoplasms (HNC) of the thyroid are rare and their malignant potential is debated.
  • Surgical management strategies for HNC vary, lacking universal consensus.
  • Distinguishing benign from malignant HNC is crucial for appropriate treatment.

Purpose of the Study:

  • To evaluate the surgical treatment outcomes for Hürthle cell neoplasms.
  • To establish criteria for differentiating benign from malignant HNC.
  • To determine the optimal surgical approach based on tumor characteristics.

Main Methods:

  • Retrospective analysis of 46 patients with HNC who underwent surgery between 1976 and 1986.
  • Preoperative diagnosis via fine needle biopsy.

Related Experiment Videos

  • Surgical procedures included total lobectomy plus isthmusectomy in most cases.
  • Histopathological and electron microscopic evaluation for malignancy criteria.

    • Main Results:

    • Hürthle cell carcinoma (HCC) can be distinguished from benign forms by experienced pathologists using invasive malignancy criteria and electron microscopy.
    • Lesions smaller than 2 cm were not considered potentially malignant and did not necessitate aggressive surgical treatment.
    • Initial treatment with hemithyroidectomy and isthmusectomy was performed, with total thyroidectomy reserved for confirmed malignancy.

    Conclusions:

    • Hemithyroidectomy and isthmusectomy represent a suitable initial surgical approach for Hürthle cell tumors.
    • Histological and electron microscopic examination are essential for diagnosing malignancy and guiding further treatment.
    • Tumor size greater than 2 cm is not a definitive indicator of malignancy in HNC.