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Related Experiment Videos

Dermatofibrosarcoma protuberans treated with radiation therapy.

L B Marks1, H D Suit, A E Rosenberg

  • 1Massachusetts General Hospital, Harvard Medical School, Boston 02114.

International Journal of Radiation Oncology, Biology, Physics
|August 1, 1989
PubMed
Summary
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Radiation therapy shows promise for treating Dermatofibrosarcoma Protuberans, an aggressive soft tissue tumor. This approach may be a viable option for unresectable lesions, with promising regression and disease-free outcomes observed in patients.

Area of Science:

  • Oncology
  • Radiation Oncology
  • Surgical Oncology

Background:

  • Dermatofibrosarcoma Protuberans (DFSP) is a rare, locally aggressive soft tissue neoplasm.
  • DFSP is characterized by a high rate of local recurrence after surgical excision.
  • Metastasis from DFSP is uncommon, but local aggressiveness poses a significant clinical challenge.

Purpose of the Study:

  • To evaluate the efficacy and safety of radiation therapy in managing Dermatofibrosarcoma Protuberans.
  • To assess radiation as a primary treatment or adjuvant therapy for DFSP.
  • To determine the role of radiation in cases of unresectable or recurrent DFSP.

Main Methods:

  • Retrospective analysis of ten patients with DFSP treated with radiation (external beam or interstitial implant) between 1979-1987.

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  • Patients received radiation alone (66.7-75 Gy) or in conjunction with surgery (preoperative/postoperative, 60-67 Gy).
  • Outcomes assessed included tumor regression, local recurrence rates, disease-free survival, and treatment-related morbidity.

    • Main Results:

    • Radiation alone resulted in complete regression and disease-free status in two of three patients at 24-26 months.
    • One patient treated with radiation alone showed slow regression over 33 months.
    • Adjuvant radiation therapy in seven patients led to disease-free survival in six (16-105 months); one patient experienced recurrence.
    • No significant treatment-related morbidity was reported.

    Conclusions:

    • Radiation therapy appears to be a viable therapeutic option for Dermatofibrosarcoma Protuberans, particularly for unresectable lesions.
    • Both radiation alone and adjuvant radiation show potential for local control and long-term disease-free survival.
    • Further investigation with longer follow-up is warranted to confirm these findings.