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Do not throw the baby out with the bath water: a guide for using non-significant results in practice

Mouaffaa Tello1, Feras Zaiem1, Mary Catherine Tolcher2

  • 1Evidence-based Practice Center, Mayo Clinic, Rochester, Minnesota, USA.

Evidence-Based Medicine
|August 20, 2016
PubMed

Insights

Interpreting non-significant research findings is difficult for healthcare providers. This study introduces a framework using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to guide clinical application of these results.

Area of Science:

  • Clinical decision-making
  • Evidence-based practice
  • Medical research interpretation

Background:

  • Clinicians face challenges in applying research results lacking statistical significance.
  • Non-significant findings are frequently dismissed as indicating no association or being irrelevant.
  • Effective use of all research evidence is crucial for optimal patient care.

Purpose of the Study:

  • To provide a structured framework for interpreting non-significant research findings.
  • To guide clinicians in applying non-significant results at the point of care.
  • To enhance the utility of all research evidence in clinical practice.

Main Methods:

  • Utilized the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach.
  • Developed a systematic framework for evaluating non-significant results.
  • Focused on practical application in clinical settings.

Main Results:

  • A clear framework for interpreting non-significant results was established.
  • Guidance was provided on how to apply these results in clinical decision-making.
  • The GRADE approach was adapted for evaluating evidence with non-significant findings.

Conclusions:

  • Non-significant results can be valuable when interpreted correctly.
  • The proposed framework facilitates the use of non-significant findings in clinical practice.
  • Implementing this approach can improve the application of research evidence by clinicians.

Keywords:
EDUCATION & TRAINING (see Medical Education & Training)EPIDEMIOLOGYOBSTETRICS

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