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Published on: January 29, 2016
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Fatigue and fluid hydration status in multiple sclerosis: A hypothesis.
Molly C Cincotta1, Matthew M Engelhard2, Makela Stankey3
1Department of Internal Medicine, School of Medicine, University of Virginia, Charlottesville, VA, USA.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|August 21, 2016
Summary
Staying hydrated may reduce fatigue in multiple sclerosis (MS) patients. This study found that individuals with multiple sclerosis (MS) and bladder dysfunction were more likely to be dehydrated, experiencing increased fatigue.
Area of Science:
- Neurology
- Clinical Research
- Public Health
Background:
- Fatigue is a common and disabling symptom in multiple sclerosis (MS), often multifactorial and poorly understood.
- Bladder dysfunction is another prevalent MS symptom impacting quality of life and social engagement.
- Reduced fluid intake to manage bladder issues may lead to dehydration and exacerbate MS fatigue.
Purpose of the Study:
- To investigate the association between patient-reported fatigue, bladder dysfunction, and hydration status in individuals with MS.
- To determine if hydration status influences the severity of MS-related fatigue.
Main Methods:
- A prospective cross-sectional study involving 50 women with MS.
- Participants provided urine samples for specific gravity (USG) measurement to assess hydration.
- Fatigue levels were evaluated using validated self-report surveys, with a USG threshold of 1.015 distinguishing high-hydration (HiH) from low-hydration (LoH) states.
Main Results:
- Low-hydration (LoH) status was more prevalent in MS subjects experiencing bladder dysfunction.
- A statistically significant difference in fatigue scores was observed between the HiH and LoH groups (p=0.022).
- Urine specific gravity (USG) showed a significant correlation with MS fatigue severity (r=0.328, p=0.020).
Conclusions:
- Hydration status is demonstrably linked to self-reported fatigue in individuals with MS.
- Maintaining adequate hydration (USG < 1.015) is associated with lower levels of fatigue.
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