Related Experiment Video
Updated: Mar 16, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Electrophysiological responses from intrinsically photosensitive retinal ganglion cells are diminished in glaucoma
Manami Kuze1, Takeshi Morita2, Yumi Fukuda2
1Department of Ophthalmology, Mie University Graduate School of Medicine, 2-174, Edobashi, Tsu, Mie 514-8507, Japan; Ophthalmology Clinic, Matsusaka Central General Hospital, 102 Kobo, Kawai-machi, Matsusaka, Mie 515-8566, Japan.
Purpose:
To record electroretinograms (ERGs) from intrinsically photosensitive retinal ganglion cells (ipRGCs) of glaucoma patients.
Methods:
ERGs were recorded in 10 normal subjects and 15 patients with glaucoma. The ERG illumination system was built to achieve receptor-silent substitution, and comprised an optical diffuser and four-in-one light-emitting diodes.
Results:
The ERG recordings of ipRGC from normal subjects showed an "on" response and an "off" response. The mean (±SD) implicit time for the on and off responses in normal subjects was 103.0±24.9 and 337.9±45.8ms, respectively, with corresponding amplitudes of 7.7±2.8 and 7.3±3.4μV, respectively. In glaucoma patients, the implicit time of the on and off responses was 135.0±28.9 and 368.2±17.3ms, respectively. The corresponding amplitudes of the on and off responses in these patients were 0.47±0.18 and 0.66±0.32μV, respectively.
Conclusions:
The results demonstrate successful ERG recording of ipRGCs from advanced glaucoma patients, with marked reductions in amplitude, although not implicit time, compared with normal subjects.
Related Concept Videos
Glaucoma: Overview
Anatomy of the Eyeball
Photoreceptors and Visual Pathways
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
The Retina

