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Published on: February 8, 2018
Comparison of SKIP expression in malignant pleural mesotheliomas with Ki-67 proliferation index and prognostic
G Türkcü1, U AlabalIk, A N Keles
1Gül Türkcü, Dicle Üniversitesi TIp Fakültesi, Sur/DiyarbakIr, Turkey, tel. 90 412 2488001, fax 90 412 2488523,
Abstract:
We aimed to determine the presence of SKI-interacting protein (SKIP) expression in malignant pleural mesothelioma (MPM) and its effect on prognosis by investigating SKIP correlation with the Ki-67 proliferation index and prognostic parameters. Pathological preparations of the patients diagnosed with MPM between 2006 and 2012 were evaluated. Immunohistochemical analyses were performed to evaluate the expression of SKIP and the Ki-67 proliferation index. Correlations between SKIP expression, clinicopathological factors and survival were investigated. Survival data were calculated using the Kaplan-Meier method, and Cox regression analysis was used to evaluate the prognostic value of the variables. In total, 52 patients were evaluated in the study; 36 of them were male and 16 were female. The mean age of the patients was 62.3 ±12.2 years. The median overall survival period was 8.5 months. Factors negatively affecting general survival in the univariate analysis included high SKIP expression, Ki-67 proliferative index over 30%, presence of non-epithelioid type MPM and stage III-IV disease (p < 0.05). Cox regression analysis revealed that high SKIP expression, high Ki-67 proliferative index and presence of non-epithelioid type MPM are independent factors that affect the survival rate. Higher SKIP expression is associated with poor prognosis in MPM.
Insights
High SKI-interacting protein (SKIP) expression indicates a poor prognosis in malignant pleural mesothelioma (MPM). SKIP correlates with proliferation and survival, independent of other factors.
Area of Science:
- Oncology
- Pathology
Background:
- Malignant pleural mesothelioma (MPM) is an aggressive cancer with limited prognostic markers.
- SKI-interacting protein (SKIP) role in MPM is not well-defined.
Purpose of the Study:
- To investigate SKIP expression in MPM.
- To determine the correlation between SKIP expression, proliferation (Ki-67), and patient prognosis.
Main Methods:
- Retrospective analysis of 52 MPM patient samples (2006-2012).
- Immunohistochemical analysis for SKIP and Ki-67 expression.
- Kaplan-Meier and Cox regression analyses for survival correlations.
Main Results:
- High SKIP expression was observed in MPM.
- High SKIP expression, high Ki-67 index (>30%), non-epithelioid type, and advanced stage (III-IV) were associated with poorer survival.
- SKIP expression is an independent negative prognostic factor in MPM.
Conclusions:
- High SKIP expression is linked to poor prognosis in malignant pleural mesothelioma.
- SKIP may serve as a valuable prognostic biomarker in MPM management.
