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Author Spotlight: Advancing Pediatric Epilepsy Surgery in Children Through Novel Biomarkers and Enhanced Localization
Published on: September 20, 2024
Focal Cortical Dysplasia in Childhood Epilepsy
Tarek Shaker1, Anne Bernier1, Lionel Carmant1
1Division of Neurology, Department of Pediatrics and Neurosciences, CHU Sainte-Justine, University of Montreal, Montreal, Quebec, Canada.
Abstract:
Focal cortical dysplasia is a common cause of medication resistant epilepsy. A better understanding of its presentation, pathophysiology and consequences have helped us improved its treatment and outcome. This paper reviews the most recent classification, pathophysiology and imaging findings in clinical research as well as the knowledge gained from studying genetic and lesional animal models of focal cortical dysplasia. This review of this recently gained knowledge will most likely help develop new research models and new therapeutic targets for patients with epilepsy associated with focal cortical dysplasia.
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