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O-GlcNAcylation, enemy or ally during cardiac hypertrophy development?

Florence Mailleux1, Roselle Gélinas2, Christophe Beauloye3

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O-linked N-acetylglucosamine (O-GlcNAcylation) regulates cellular processes and cardiac hypertrophy. This review explores O-GlcNAcylation

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • O-linked attachment of β-N-acetyl-glucosamine (O-GlcNAcylation) is a dynamic post-translational modification on serine and threonine residues.
  • O-GlcNAcylation plays a crucial role in regulating diverse cellular functions and is implicated in various pathologies.
  • This modification is increasingly recognized for its significance in cardiovascular health and disease.

Purpose of the Study:

  • To provide a comprehensive overview of the molecular regulation of protein O-GlcNAcylation.
  • To summarize the role of O-GlcNAcylation in acute cardiac pathologies, specifically ischemia-reperfusion.
  • To critically examine the involvement of O-GlcNAcylation in different types of cardiac hypertrophy and its therapeutic potential.

Main Methods:

  • Literature review of existing research studies on O-GlcNAcylation and cardiac hypertrophy.
  • Analysis of O-GlcNAcylated targets involved in the development of cardiac hypertrophy.
  • Synthesis of findings to distinguish the beneficial or detrimental effects of O-GlcNAcylation in cardiac hypertrophy.

Main Results:

  • O-GlcNAcylation impacts various cellular processes and is involved in acute cardiac conditions like ischemia-reperfusion.
  • The role of O-GlcNAcylation in cardiac hypertrophy is complex, with convergent and divergent effects depending on the type of hypertrophy (physiological, pressure overload, diabetes-linked).
  • Specific O-GlcNAcylated protein targets have been identified that contribute to hypertrophy development.

Conclusions:

  • O-GlcNAcylation is a key post-translational modification with significant implications for cardiac health and disease.
  • Targeting O-GlcNAcylation pathways presents a potential therapeutic strategy for treating cardiac hypertrophy.
  • Further research is warranted to fully elucidate the dual role of O-GlcNAcylation in cardiac pathologies.