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Corynebacterium ulcerans, an emerging human pathogen.

Elena Hacker1, Camila A Antunes1,2, Ana L Mattos-Guaraldi2

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|August 23, 2016
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Summary
This summary is machine-generated.

Corynebacterium ulcerans, a zoonotic pathogen, is emerging globally. This review details its basic knowledge and advances in analyzing virulence factors, crucial for understanding host colonization and disease.

Keywords:
Corynebacteriumdiphtheriahost–pathogen interactionmastitisnext-generation sequencingzoonosis

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genomics

Background:

  • Corynebacterium ulcerans infections were historically rare and linked to cattle.
  • C. ulcerans is now an emerging zoonotic pathogen, with increasing reports of respiratory diphtheria and systemic infections in Western Europe.
  • Limited understanding exists regarding factors driving C. ulcerans host colonization and virulence.

Purpose of the Study:

  • To provide a comprehensive overview of current knowledge on C. ulcerans.
  • To summarize recent advancements in analyzing the putative virulence factors of C. ulcerans.
  • To highlight the significance of newly available C. ulcerans genome sequences.

Main Methods:

  • Literature review of C. ulcerans epidemiology and pathogenesis.
  • Analysis of published C. ulcerans genome sequences.
  • Synthesis of research on C. ulcerans virulence factors.

Main Results:

  • C. ulcerans is increasingly prevalent, surpassing C. diphtheriae in some regions for respiratory diphtheria.
  • Genomic data is providing new insights into C. ulcerans biology.
  • Several putative virulence factors are under investigation.

Conclusions:

  • C. ulcerans represents a growing public health concern.
  • Further research into its virulence factors is essential for effective control strategies.
  • Genomic studies are pivotal for understanding this emerging pathogen.