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Allergic Reactions02:06

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Overview
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Asthma-I: Introduction01:29

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
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Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
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Indoor and Outdoor Allergies.

Madhavi Singh1, Amy Hays2

  • 1Department of Family and Community Medicine, Penn State Hershey Medical Group, 1850 East Park Avenue, Suite 207, State College, PA 16803, USA.

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|August 23, 2016
PubMed
Summary

Allergy incidence has risen significantly due to environmental factors like air pollution and lifestyle changes, not just genetics. Effective management includes allergen avoidance and immunotherapy.

Keywords:
Air pollutionAllergensDust mitesIndoor allergiesMold allergiesOutdoor allergiesPollens

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Area of Science:

  • Environmental Science
  • Immunology
  • Public Health

Background:

  • Significant increase in allergy incidence over the past 30-40 years.
  • Genetic factors alone do not explain the rising allergy rates.
  • Environmental factors like air pollution and lifestyle changes are key contributors.

Purpose of the Study:

  • To summarize the contributing factors to the increasing incidence of allergy.
  • To highlight the role of environmental factors and lifestyle changes in allergy development.
  • To outline current management strategies for allergic diseases.

Main Methods:

  • Review of recent epidemiological trends in allergy.
  • Analysis of the impact of air pollution on allergic sensitization.
  • Identification of common indoor and outdoor allergens.
  • Summary of treatment modalities including allergen avoidance and immunotherapy.

Main Results:

  • Allergy incidence has markedly increased, driven by environmental factors.
  • Indoor allergens (dust mites, molds, animals) and outdoor allergens (tree/grass pollens) are primary sensitizers.
  • Air pollution exacerbates allergy symptoms and related health issues.
  • Cross-sensitization among allergens is a common phenomenon.

Conclusions:

  • The rise in allergy is multifactorial, with significant contributions from environmental exposures and lifestyle.
  • Managing allergies requires a comprehensive approach including allergen avoidance, lifestyle modification, and medical interventions.
  • Further research into the interaction of pollution and allergens is warranted to mitigate the growing allergy burden.