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Updated: Mar 16, 2026

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
Published on: September 19, 2017
Controlling molecularity and stability of hydrogen bonded G-quadruplexes by modulating the structure's periphery
Keith B Sutyak1, Peter Y Zavalij, Michael L Robinson
1Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA. jdavis@umd.edu.
Abstract:
We report on self-assembly of guanosines with aromatic esters at their 5'-position. Depending on the basicity of the 5'-ester either discrete octamers G8·K(+)I(-) or hexadecamers G16·3K(+)3I(-) are formed. The thermodynamic and kinetic stabilities of the G-quadruplex can be controlled by interlayer hydrogen-bonding and by dispersion interactions on the assembly's periphery.
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