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Related Experiment Video

Updated: Jan 13, 2026

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

Published on: April 11, 2020

Protein adsorption on nanoparticles: model development using computer simulation.

Qing Shao¹, Carol K Hall

¹Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, NC 27695, USA.

Journal of Physics. Condensed Matter : an Institute of Physics Journal

|August 23, 2016

Summary

This summary is machine-generated.

Protein corona formation on nanoparticles is modeled using computer simulations. Adsorption isotherms were well-described by specific models, highlighting challenges in developing generalized nanoparticle-protein interaction models.

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Last Updated: Jan 13, 2026

Study of Short Peptide Adsorption on Solution Dispersed Inorganic Nanoparticles Using Depletion Method

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Published on: April 11, 2020

Ligand-Mediated Nucleation and Growth of Palladium Metal Nanoparticles

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Monitoring Protein Adsorption with Solid-state Nanopores

Monitoring Protein Adsorption with Solid-state Nanopores

Published on: December 2, 2011

Area of Science:

Nanotechnology
Biophysics
Computational Chemistry

Background:

The protein corona, formed by protein adsorption on nanoparticles, dictates nanoparticle interactions with biological systems.
Understanding protein adsorption is crucial for predicting nanoparticle behavior in biological environments.

Purpose of the Study:

To develop models for protein adsorption on nanoparticles using computer simulation data.
To investigate the influence of nanoparticle size and protein concentration on protein corona formation.

Main Methods:

Discontinuous molecular dynamics simulations with a coarse-grained protein model.
Investigation of Trp-cage and WW domain adsorption on 10.0 nm nanoparticles at varying concentrations (0.5–5 mM).
Evaluation of adsorption isotherm models (Langmuir, Freundlich, Temkin, Kiselev, Elovich, Fowler-Guggenheim, Hill-de Boer).

Main Results:

Adsorption isotherms were accurately described by Langmuir, Freundlich, Temkin, and Kiselev models.
Elovich, Fowler-Guggenheim, and Hill-de Boer models did not adequately describe the simulation results.
Initial attempts at a generalized model for varying nanoparticle sizes (5.0–20.0 nm) showed promise but also highlighted challenges.

Conclusions:

Specific thermodynamic models effectively describe protein adsorption equilibrium on nanoparticles.
Developing generalized models for protein adsorption across different nanoparticle sizes requires further refinement.
Simulation-based modeling provides valuable insights into protein corona formation dynamics.