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Olanzapine Induced Dilated Cardiomyopathy.
Beeresha Puttegowda1, Joseph Theodore1, Ramesh Basappa1
1Department of Cardiology, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Pin: 560069, India.
The Malaysian Journal of Medical Sciences : MJMS
|August 23, 2016
Summary
This case study highlights a rare instance of potential olanzapine-induced cardiomyopathy in a bipolar disorder patient. The study emphasizes the need to consider atypical antipsychotic side effects in unexplained heart failure.
Area of Science:
- Cardiology
- Psychiatry
- Pharmacology
Background:
- Bipolar disorder management often involves atypical antipsychotics like olanzapine.
- Long-term use of olanzapine is associated with metabolic side effects, including weight gain and diabetes.
- Cardiovascular complications are a concern in patients with chronic mental health conditions.
Observation:
- A 28-year-old male with bipolar disorder on long-term olanzapine and lorazepam presented with significant weight gain, diabetes, and anasarca.
- Clinical evaluation revealed the patient was in heart failure.
- Initial investigations for the cause of heart failure were inconclusive.
Findings:
- A literature review identified a few reported cases of putative olanzapine-induced cardiomyopathy.
- This case presents a rare instance potentially linking olanzapine use to the development of heart failure.
Implications:
- Clinicians should consider drug-induced cardiomyopathy, particularly with olanzapine, in patients presenting with unexplained heart failure.
- Further research is warranted to elucidate the mechanisms and prevalence of olanzapine-associated cardiac dysfunction.
- Monitoring for cardiovascular health is crucial in patients on long-term atypical antipsychotic therapy.
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