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Towards a multidimensional healthy ageing phenotype.

Sarah Mount1, Jose Lara, Annemie M W J Schols

  • 1aDepartment of Respiratory Medicine, Maastricht University Medical Centre, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands bHuman Nutrition Research Centre, Institute of Cellular Medicine and Institute for Ageing, Newcastle University cDepartment of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.

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Developing tools to measure healthy ageing is crucial for early health impairment detection. Recent advancements focus on novel markers and longitudinal data to better define healthy ageing trajectories.

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Area of Science:

  • Gerontology
  • Public Health
  • Biomedical Sciences

Background:

  • There is a growing need for validated tools to measure healthy ageing.
  • Early identification of health impairment can guide interventions to prevent disease and mortality.
  • Current definitions and measurement tools for healthy ageing lack consensus.

Purpose of the Study:

  • To review recent developments in operationalizing and testing definitions of healthy ageing.
  • To explore advancements in measuring the healthy ageing phenotype.
  • To identify future directions for defining and measuring healthy ageing.

Main Methods:

  • Review of recent literature on healthy ageing measurement.
  • Analysis of instruments and markers used to assess the healthy ageing phenotype.
  • Examination of cross-sectional and longitudinal data approaches.

Main Results:

  • Progress has been made in describing and devising tools for the healthy ageing phenotype.
  • Recent studies utilize markers from multiple functional domains and longitudinal data.
  • Existing methods often rely on older cohort data, limiting detection of subtle declines.

Conclusions:

  • No single measure can predict ageing trajectories due to complexity.
  • Current operationalizations are limited by historical data and tools.
  • Future research should employ objective and novel markers for a more accurate definition of healthy ageing.