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Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
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Gut microbiota in chronic kidney disease
Secundino Cigarran Guldris1, Emilio González Parra2, Aleix Cases Amenós3
1Sección de Nefrología, Hospital Da Costa, Burela (Lugo), España.
Summary
In chronic kidney disease (CKD), an imbalanced gut microbiome and increased intestinal permeability lead to harmful toxins. These factors contribute to inflammation, oxidative stress, and CKD complications, suggesting therapeutic interventions.
Area of Science:
- Microbiology
- Nephrology
- Gastroenterology
Background:
- Intestinal microflora imbalance (dysbiosis) is linked to diseases.
- Chronic kidney disease (CKD) patients exhibit dysbiosis and increased intestinal permeability.
- Gut bacteria produce toxins (indoles, phenols, amines) that accumulate in CKD.
Purpose of the Study:
- To describe the gut microbiome alterations in CKD.
- To explain the consequences of increased intestinal permeability in CKD.
- To discuss CKD complications linked to gut-derived uremic toxins and potential therapies.
Main Methods:
- Review of existing literature on intestinal microflora in CKD.
- Analysis of the relationship between gut dysbiosis, intestinal barrier function, and CKD.
- Exploration of therapeutic strategies targeting the gut microbiome.
Main Results:
- CKD is associated with pathogenic gut flora and a compromised intestinal barrier.
- Gut-derived uremic toxins accumulate in CKD, promoting inflammation and oxidative stress.
- These alterations contribute to CKD complications like cardiovascular disease and anemia.
Conclusions:
- Gut dysbiosis and barrier dysfunction are significant factors in CKD.
- Gut-derived uremic toxins exacerbate CKD progression and complications.
- Interventions like prebiotics, probiotics, and synbiotics may improve CKD outcomes.
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