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Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
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Mutations are heritable changes in an organism’s genome involving alterations in the base sequence of DNA or RNA. These changes can influence cellular processes and phenotypic traits, potentially transforming the unaltered wild type into a mutant form. Such changes, termed forward mutations, are pivotal in shaping the genetic diversity of organisms.RNA viruses exhibit the highest mutation rates due to the absence of robust proofreading mechanisms during genome replication. In contrast,...
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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Related Experiment Video

Updated: Mar 16, 2026

Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
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Fungal Evolution: Mucor and Phycomyces See Double.

Jason E Stajich1

  • 1Department of Plant Pathology & Microbiology and Institute for Integrative Genome Biology, University of California-Riverside, Riverside, CA 92521, USA.

Current Biology : CB
|August 25, 2016
PubMed
Summary

Genome sequencing of Mucoralean fungi reveals an ancient whole-genome duplication event. This duplication expanded gene families and likely contributed to their complex light-sensing abilities.

Area of Science:

  • Fungal genomics
  • Evolutionary biology
  • Molecular biology

Background:

  • Mucoralean fungi possess complex responses to environmental stimuli.
  • Understanding fungal genome evolution provides insights into gene family expansion and adaptation.

Purpose of the Study:

  • To investigate the genomic basis of whole-genome duplication in Mucoralean fungi.
  • To explore the relationship between genome evolution and light-sensing mechanisms in these fungi.

Main Methods:

  • Comparative genomics using newly available genome sequences of Phycomyces blakesleeanus and Mucor circinelloides.
  • Analysis of gene families and gene networks involved in light sensing and signaling.

Main Results:

  • Evidence for an ancient whole-genome duplication event in the studied Mucoralean fungi.

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  • Identification of expanded gene families potentially arising from this duplication.
  • Correlation between robust light responses and expanded gene networks for light sensing and signaling.
  • Conclusions:

    • Whole-genome duplication is a significant factor in the evolutionary history of Mucoralean fungi.
    • Gene family expansion following duplication likely facilitated the development of sophisticated light responses.