Related Experiment Video
Updated: Mar 16, 2026
08:51
Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
Published on: August 24, 2019
10.8K
The Association Between Barium Examination and Subsequent Appendicitis: A Nationwide Population-Based Study
Hao-Ming Li1, Lee-Ren Yeh1, Ying-Kai Huang2
1Department of Radiology, E-Da Hospital and I-Shou University, Kaohsiung, Taiwan.
The American Journal of Medicine
|August 25, 2016
Summary
Barium examination (BE) is linked to a higher risk of appendicitis, particularly in the initial two months post-procedure. This association highlights a potential diagnostic challenge that clinicians must consider for timely appendicitis diagnosis.
Area of Science:
- Gastroenterology
- Radiology
- Epidemiology
Background:
- The relationship between barium examination (BE) and subsequent appendicitis risk is not well-established.
- Potential risks associated with BE may be overlooked in clinical practice.
Purpose of the Study:
- To investigate the association between barium examination and the risk of developing appendicitis.
- To quantify the appendicitis risk in patients who have undergone BE.
Main Methods:
- A nationwide, population-based cohort study utilizing the Taiwan National Health Insurance Research Database.
- Inclusion of 24,885 patients who underwent BE and 98,384 matched controls without BE exposure.
- Analysis using Kaplan-Meier curves, log-rank test, and Cox proportional hazards regression.
Main Results:
- The cumulative incidence of appendicitis was significantly higher in the BE cohort (1.19 per 1000 person-years) compared to the non-BE cohort (0.80 per 1000 person-years).
- Adjusted analyses revealed a 1.46-fold increased risk of appendicitis in the BE cohort (aHR = 1.46, 95% CI = 1.23-1.73).
- A markedly elevated risk was observed within the first two months post-BE (aHR = 9.72, 95% CI = 4.65-20.3).
Conclusions:
- Barium examination is associated with a time-dependent increase in appendicitis risk.
- Clinicians should maintain a high index of suspicion for appendicitis in patients with recent BE to prevent diagnostic delays.
Related Concept Videos
01:23Lower GI Series: Barium Enema
2.2K
A Barium Enema, or a lower GI series, is a specialized radiographic examination designed to visualize the lower gastrointestinal tract, specifically the colon and rectum. This procedure is instrumental in diagnosing various conditions such as colorectal cancer, polyps, diverticulosis, and inflammatory bowel disease.
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
Procedure Details
The examination begins by inserting a lubricated rectal tube into the patient's rectum to administer a radiopaque barium solution. The barium flow is carefully...
2.2K
01:22Appendicitis-I: Introduction
3.2K
The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
3.2K
01:29Appendicitis-II: Diagnostic Studies and Management
710
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
710
01:24Upper GI Series: Barium Swallow
2.1K
The Barium Swallow Study, or a Barium Esophagogram, is a diagnostic imaging method used to visualize the upper gastrointestinal (GI) tract, including the esophagus, stomach, and small intestine. It employs barium sulfate, a radiopaque contrast material, to provide clear images of the upper digestive system, helping to identify abnormalities, diseases, or structural issues.
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
Purpose and Procedure
Patients undergoing this procedure ingest a liquid containing barium sulfate with a chalky...
2.1K
01:25Assessment of the Rectum and Anus
1.6K
Evaluating the rectum and anus plays a crucial role in conducting a thorough physical examination of the gastrointestinal system. Although it may be uncomfortable and often embarrassing for the patient, it holds immense diagnostic value, particularly in detecting gastrointestinal diseases and abnormalities. This guide will explain how to perform this assessment using inspection and palpation methods.
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
Rectal Inspection
Begin by inspecting the perianal and anal areas for color, texture, rashes,...
1.6K
01:26Endoscopic Procedures V: ERCP
5.1K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Patient...
5.1K